I agree; edited accordingly. Retrieved 7 May Archived from the original on Retrieved 21 January I happen to agree with you that the flares lighting up in the endosome is a serious issue to be addressed and most certainly interferes with accurate detection of mRNA. You are commenting using your Twitter account.
Reference  correspond to six half a dozen articles, 80a to 80f see below for details and links. Phoenix, Arizona , U. He is the founding editor of the nanotechnology journal Small , and he is an associate editor of the Journal of the American Chemical Society. But keep in mind that the same gene regulation effect can be seen with multivalent oligonucleotide nanoparticles of varying cores, such as self-assembled micellar structures, e. Rathmann professor of chemistry, professor of medicine, professor of materials science and engineering , professor of biomedical engineering , and professor of chemical and biological engineering, and director of the International Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly at Northwestern University.
Learn how your comment data is processed. He is the George B. Beckman Young Investigators, — A common strategy used by Mirkin’s group is the use of the unique properties of spherical nucleic acids SNAsspherical arrangements of nucleic acids with or without organic or inorganic nanoparticle cores, to enable the synthesis of novel materials and colloidal crystals, the development of high sensitivity mirkkn for chemical and medical diagnostic purposes, and single-entity structures capable of intracellular gene regulation.
Archived from the original on 14 November Some readers might wonder why I am going on about this, so let me tell you: Well, you said it yourself: In fact, taking advantage of lower endosomal pH to dissociate nucleic acid carriers is a well-known strategy for facilitating endosomal escape of oligonucleotides.
Antisense gene regulation cannot happen without the particles going out of the endosomes.
Do yhesis oligonucleotides enter with or without the AuNPs? Fill in your details below or click an icon to log in: Patents related to therapeutically targeting Nodal in tumor cells have been awarded to E. Notify me of new comments via email.
This site uses Akismet to reduce spam. If desorption occurs due to breaking of the Au-S bond, there cannot be specificity. Wilhelm Exner Medal; William H.
They are being tested for antisense gene regulation, which has been demonstrated both in vivo and in vitro. You are commenting using your Google account.
A RESPONSE FROM CHAD MIRKIN’S GROUP [follow up #1/n] | Rapha-z-lab
Dickinson CollegePennsylvania State University. It seems you are unfamiliar with the literature. This could be accomplished either through a pH-dependent mechanism or in response to something like glutathione which has a much higher concentration in the cytosol: The report produced by the committee calls for midkin the investments in advanced science and technology that produced America’s innovation economy and the establishment of a National Network of Manufacturing Innovation Institutes.
Calling the clinical trials for spherical nucleic acids into question is disingenuous.
Retrieved 17 November And no, the papers on nano-flares are not underpinning the clinical trials, the papers on gene regulation are. I agree; edited accordingly. It assumes it does. Why is there no direct evidence when it would be so easy to do and even with some efforts quantify?
He also co-chaired the PCAST report titled, “Engage to Excel,” focusing on teaching and engagement issues involving students who are in their first two years of undergraduate study at R-1, 2 and 4-year institutions, and community colleges.
Chad Mirkin – Wikipedia
The author is a journalist working for the magazine, not a practicing scientist. Reference  correspond to six half a dozen articles, 80a to 80f see below for details and links. CoI statement from the paper: Polyplex, Can you summarize the mechanism by which the oligonucleotides escape the endosome and interact with intracellular RNA?
Yes, your summary is pretty much what I thssis getting at.
Retrieved January 31,